IDENTIFICATION OF COMPOUNDS IN SOURSOP LEAVES (Annona muricata L) AS BREAST ANTICANCER AGAINST ALFA ESTROGEN RECEPTORS BY MOLECULAR DOCKING

Muhammad Fauzi(1*), Nur Aini(2), Auliana Auliana(3), Syarifah Rugayah(4), Ciara Fitri Pribadi(5), Rizki Rahmadi Pratama(6)

(1) Faculty of Pharmacy, “Islamic University of Kalimantan. Jl. Adhiyaksa No. 2 Kayu Tangi, Banjarmasin, Indonesia
(2) Faculty of Pharmacy, “Islamic University of Kalimantan. Jl. Adhiyaksa No. 2 Kayu Tangi, Banjarmasin, Indonesia
(3) Faculty of Pharmacy, “Islamic University of Kalimantan. Jl. Adhiyaksa No. 2 Kayu Tangi, Banjarmasin, Indonesia
(4) Faculty of Pharmacy, “Islamic University of Kalimantan. Jl. Adhiyaksa No. 2 Kayu Tangi, Banjarmasin, Indonesia
(5) Faculty of Pharmacy, “Islamic University of Kalimantan. Jl. Adhiyaksa No. 2 Kayu Tangi, Banjarmasin, Indonesia
(6) Faculty of Pharmacy, “Islamic University of Kalimantan. Jl. Adhiyaksa No. 2 Kayu Tangi, Banjarmasin, Indonesia
(*) Corresponding Author

Abstract


The incidence of breast cancer in Indonesia is steadily rising. Women have the highest incidence of breast cancer. Acetogenins are highly effective inhibitors of mitochondrial complex I or NADH dehydrogenase, making them a promising option for therapeutic creation against breast cancer. The plant known as Annona muricata, also referred to as the soursop leaf plant, is purported to possess the ability to suppress the activity of breast cancer. Hence, it is imperative to assess the chemical composition of soursop leaves on receptors by docking experiments. Research utilizing the active site on the alpha estrogen receptor has determined that the reticulin molecule, with a free energy of -8.14 kcal/mol, is a potential contender for breast cancer therapeutic medications. Reticulin exhibits the highest affinity for binding to the active site of estrogen receptor alpha. This chemical exhibits the capacity to impede the growth of breast cancer.


Keywords


Soursop Leaves; Alpha Estrogen; Breast Cancer; Molecular Docking

Full Text:

PDF

References


Apriliani, I. M., Purba, N. P., Dewanti, L. P., Herawati, H., & Faizal, I. (2024). Efektivitas Media Edukasi Sadari Terhadap Deteksi Dini Kanker Payudara, Jurnal Kesehatan, 2(1), 56–61.

Agreno, M., Darmi, N. F., Ismy, J., Erdani, F., & Hidayat, I. (2022). Pengaruh Periode Penggunaan Tamoxifen Terhadap Kejadian Endometriosis Pada Penderita Kanker Payudara. Journal of The Indonesian Medical Association, 71, 259-266.

Dewayani, A. R., Ghaliya, S., Parameswari, N., Pribadi, A. P. A., Ahadi, H. M., Aulifa, D. L., ... & Sitinjak, B. D. P. (2023). Studi In Silico Senyawa Daun Sirsak (Annona muricata L.) Sebagai Inhibitor BRAF V600E Kinase Pada Kanker Melanoma. Jurnal Farmasi.

Dewi, T. J. D., Ariqoh, S. S., & Wafi, A. (2023). Studi In Silico Senyawa Alkaloid dari Daun Sirsak (Annona muricata L.) Sebagai Inhibitor Angiotensin Converting Enzyme (ACE). Journal of Islamic Pharmacy, 8(2), 108-113.

Ding, Y., Fang, Y., Moreno, J., Ramanujam, J., Jarrell, M., & Brylinski, M. (2016). Assessing the similarity of ligand binding conformations with the Contact Mode Score. Computational Biology and Chemistry, 64, 403–413.

Fadhil, M., Harahap, W. A., & Rusnita, D. (2019). Hasil Pengobatan Adjuvan Tamoxifen pada Pasien Kanker Payudara di RSUP Dr. M. Djamil Padang. Cermin Dunia Kedokteran, 46(12), 748-752.

Fauzi, M., Fadillah, A., Rahman, F., Ramadhani, J., Erlianti, K., Hasniah, Y. B. S., & Malik, A. (2021). Activity Screening And Structure Modification Of Artocarpin Against Ace2 And Main Protease Through In Silico Method. Int J App Pharm, 13(6), 192-198.

Fauzi, M., & Muchtaridi, M. (2020). Synthesis and anti-breast cancer activities of alpha mangostin derivatives: a review. Cancer, 13(4), 2544-2551.

Fauzi, M., Rahman, F., Soemari, Y. B., & Purnamasari, R. (2021). Prediksi Senyawa Eucalyptus sebagai Inhibitor Potensial Covid-19 Main Protease (Mpro) secara Molecular Docking. Al Ulum: Jurnal Sains Dan Teknologi, 6(2), 77-83.

Jindal A, Mohi MK, Kaur M, Kaur B,Singla R, Singh S. (2015). Endometrial evaluation byultra-sonography, hysteroscopy and histopathology in cases of breast carcinoma on Tamoxifen therapy. J Midlife Health. 6(2):59-65.

Kusumastuti, M. S. T., & Cholisoh, Z. (2024). Gambaran Adverse Drug Reactions (Adrs) Pada Pasien Kanker Payudara yang Mendapatkan Adjuvant Endocrine Therapy (Aet) Tamoxifen dan Faktor-Faktor yang Mempengaruhinya di Rs Swasta Semarang Tahun 2023. Jurnal Ners, 8(1), 96-101.

Mun’iem, F., Damayanti, D. S., & Hakim, R. (2023). Prediksi Daun Annona Muricata Linn. Sebagai Antidiabetes Melalui Aktifasi Protein SUR-1 Dan Inhibisi SGLT-2 Dengan Studi In Silico. Jurnal Kedokteran Komunitas (Journal of Community Medicine), 11(2).

Muthmainna, B., & Usman, Y. (2024). Pelatihan Pembuatan Simplisia Daun Sirsak (Annona muricata) Pada Ibu Rumah Tangga Desa Mangangeloreng Kecamatan Bantimurung. Indonesian Journal of Community Dedication, 6(1), 7–10.

Qhoiriyah, S., Andalia, E., Rozalinda, E., Yuliyana, Resti, R., Giantarari, Soresmi, & Utami, I. T. (2024). Peningkatan Pengetahuan Tentang Pencegahan Kanker Payudara Dengan Teknik Sadari. Jurnal Kesehatan, 6(1), 58–63.

Pratiwi, S. R., Widianti, E., & Solehati, T. (2017). Gambaran faktor-faktor yang berhubungan dengan kecemasan pasien kanker payudara dalam menjalani kemoterapi. Jurnal Pendidikan Keperawatan Indonesia, 3(2), 167-174.

Ramandhita, A. P., & Hanum, L. (2021). Efek Antikanker Nanopartikel Alginat Ekstrak Etanol Daun Sirsak (Annona muricata Linn) pada Kultur Sel Kanker Hepar (HepG2). Jurnal Riset Kedokteran, 130-133.

Taqiyah, Y., Asri, A. N., & Fauziah, F. (2022). Hubungan Pengetauan Dan

Sikap Terhadap Pencegahan Kanker Payudara. Borneo Nursing Journal (BNJ), 4(2), 58-63.

Thayyib, H., Muis, M., & Murtala, B. (2020). Gambaran ultrasonografi kelainan endometrium pada penderita kanker payudara yang mendapat terapi hormonal di Rumah Sakit Wahidin Sudirohusodo. Nusantara Medical Science Journal, 87-96.

Yulianti, I., Santoso, H. S., & Sutinigsih, D. (2016). Faktor-faktor risiko kanker payudara (studi kasus pada Rumah Sakit Ken Saras Semarang). Jurnal Kesehatan Masyarakat, 4(4), 401-409




DOI: http://dx.doi.org/10.31602/jst.v10i2.15784

Refbacks

  • There are currently no refbacks.


Copyright (c) 2024 Muhammad Fauzi, Nur Aini, Auliana; Syarifah Rugayah, Ciara Fitri Pribadi, Rizki Rahmadi Pratama

E-ISSN  2477- 4731

Al Ulum: Jurnal Sains dan teknologi = Al Ulum: Jurnal Science and Technology by Islamic University of Kalimantan is licensed under a Creative Commons Attribution 4.0 International License. Based on a work at http://ojs.uniska-bjm.ac.id/index.php/JST.